For the first time we report while absolute renal content of Ang1–7 was significantly lower in the renal cortex of uni-x animals consistent with observations in untreated essential hypertensive subjects [54], the proportion of basal expression of Ang1–7 to AngII was significantly greater in the uni-x animals compared to the sham kidney cortex whilst levels in medulla were not different. The gene discussed is AGT; the disease is essential hypertension.