Overexpression of CDC25B and/or CDK2-cyclin E/A, which are commonly found in a wide range of human cancers, may therefore be sufficient, through centrosomal substrates like Mps1, to promote the formation of extra-numerary centriolar foci that can mature into functional centrosomes and potentiate chromosome misegregation and aneuploidy, through the formation of aberrant multipolar mitotic spindles. Here, CDC25B is linked to cancer.