Overexpression of CDC25B and/or CDK2-cyclin E/A, which are commonly found in a wide range of human cancers, may therefore be sufficient, through centrosomal substrates like Mps1, to promote the formation of extra-numerary centriolar foci that can mature into functional centrosomes and potentiate chromosome misegregation and aneuploidy, through the formation of aberrant multipolar mitotic spindles. This evidence concerns the gene CDK2 and cancer.