Table 1 shows, as example, some of the known Furin substrates that could be studied with our assay. However, this assay system targets all the enzymes that cleave within the luminal face of the ER/Golgi/TGN compartment, including non-Furin PC and SP family members, or the β-site amyloid precursor protein cleaving enzyme (β-secretase), critical for the onset of Alzheimer’s disease [7,9,16]. This evidence concerns the gene FURIN and early-onset autosomal dominant Alzheimer disease.