TP53 and neoplasm: At final measurement, DIO mice, relative to control mice, had significantly increased Wnt-1 p53+/+ tumor weight (P = 0.044; Figure 3B) and volume (P = 0.010; Figure 3D), and significantly increased Wnt-1 p53+/− tumor weight (P = 0.022; Figure 3C) and volume (P = 0.005; Figure 3E).