In contrast, Wnt-1 p53+/+ mammary tumors from DIO mice and Wnt-1 p53+/− mammary tumors from control mice or DIO mice were all poorly differentiated ductal adenocarcinomas with disorganized ductal structures, papillary and cystic structures and wide spread central necrosis. Here, WNT1 is linked to invasive ductal breast carcinoma.