CFH and age-related macular degeneration: Linkage analyses and candidate gene approaches have found significant association of AMD with sequence variants in the genes for complement factor H (CFH) [17], [18], [19], [20] and the CFH-related gene cluster [21], [22] on human chromosome 1 and with the gene for the serine protease HTRA1 [23] or the neighboring LOC387715[24] on chromosome 10.