CASP3 and thyroid tumor: Furthermore, the increased cleaved caspase 3 (Figure 4A, panel b, lanes 3 & 4) and the decreased total poly ADP-ribose polymerase (PARP) but increased cleaved PARP (panel c, upper band and lower band, respectively, in lanes 3 & 4) in ThrbPV/PVNcor1ΔID/ΔID mice as compared with ThrbPV/PVNcor1+/+ mice were indicative of the elevated apoptotic activity in thyroid tumor cells of ThrbPV/PVNcor1ΔID/ΔID mice (also see quantitative data in Figure 4Bb).