Ko et al showed that the combination of an adenovirus encoding human (xenogeneic) Her-2/neu, a low-dose chemotherapeutic gemcitabine (also known to deplenish MDSCs) and the Treg suppressive antibody, anti-GITR, was capable of causing tumor regressions in a murine colon cancer model where the cancer cell line used was transfected with syngeneic Her-2/neu [34]. This evidence concerns the gene TNFRSF18 and colonic neoplasm.