Our results regarding the observed decrease in primitive hematopoiesis in the Actb−/− embryo are consistent with the observed anemia and lethality at E10.5 in Gata2 knockout embryos [23] indicating that the diminished expression of Gata2 contributes to this phenotype in the Actb−/− embryos. This evidence concerns the gene GATA2 and anemia (phenotype).