Figure 4C shows that the levels of E-cadherin expression, ERK1/2 phosphorylation, and cytoplasmic PKM2 expression were correlated with each other. In addition, we observed a high level of ERK1/2 phosphorylation in the nucleus of cancer cells without E-cadherin expression. In areas of ERK1/2 phosphorylation, we also found higher levels of PKM2 expression. However, we did not find the phosphorylation of ERK1/2 in areas positive for E-cadherin expression (Fig. 4C). A correlation analysis among PKM2, E-cadherin and P-ERK1/2 was performed using Image-pro Plus software (Fig. 4D). Here, MAPK3 is linked to cancer.