We observed positive expression of EFEMP1 in 19.1% (16/84) of carcinomas, which was significantly lower than that seen in 80% of normal endometrium (32/40) and 70% of atypical hyperplasia (7/10) respectively (P<0.001 and P = 0.02, Table 1, Table S1and S2). The gene discussed is EFEMP1; the disease is carcinoma.