Patients with IDH1 wild-type astrocytomas had shorter OS (median 65 months) and PFS (median 33.9 months) than those with IDH1mutated astrocytomas (median OS 23 months, p<0.001; median PFS 14 months, p = 0.001) (Figure 2A and 2B). This evidence concerns the gene IDH1 and astrocytoma (excluding glioblastoma).