In a recently published Aliskiren in the eValuation of prOteinuria In Diabetes (AVOID) substudy, the Uald-24 h was chosen over PAC to assess the effects of direct renin inhibition with aliskiren in combination with losartan, as the urinary analysis better reflects the mean aldosterone level than random plasma samples due to the diurnal variation of plasma aldosterone levels [25]. The gene discussed is REN; the disease is Proteinuria.