CDH1 and neoplasm: To determine the independent predictors for clinical parameters, tumor burden, nodal involvement and clinical stage, logistic regression analysis was carried out in a stepwise manner for E-cadherin, β-catenin and ALCAM individually, or in combination, in 105 OSCCs (Table 3). β-catenin membrane loss (p = 0.001, OR = 4.2; 95% C.I. = 1.8–10.2) and β-catenin nuclear/cytoplasmic accumulation (p = 0.027, OR = 3.1; 95% CI = 1.1–8.3) were the most significant predictors for increased tumor burden.