Multivariate analysis of expression of these three proteins in clinical specimens from patients diagnosed with oral hyperplasia, dysplasia and SCC, provided the first evidence of concomitant expression of cytoplasmic/reduced membranous expression of ALCAM and loss of membranous E-cadherin and β-catenin in early OLs, dysplasia and sustained in OSCC. This evidence concerns the gene CDH1 and dysplasia.