Thus, in the present study the role of NMDARs in the MS phenotype was explored in subjects carrying specific allelic variants in the NR1 subunit gene (GRIN1 rs4880213 and rs6293) or the NR2B subunit gene (GRIN2B rs7301328 and rs1805247). The gene discussed is GRIN2B; the disease is myeloid sarcoma.