In grade 3 and some grade 2 breast tumors, impairment of TGFβ-mediated signaling intermediates, often due to inactivating mutations [34], results in the derepression of these oncogenes, enabling an escape from TGFβ-dependent growth modulation, and culminating in an overall aggressive tumor phenotype. The gene discussed is TGFB1; the disease is breast neoplasm.