Moreover, siRNA-mediated silencing of ILK in MDA-MB-231, PC-3, and other cell lines examined resulted in inhibition of Ser473-Akt phosphorylation and induction of apoptosis [42], [43], and the small-molecule inhibitors of ILK, QLT0267 [21], [32], [42], [43], [44], [45], [46], [47], [48], [49], [50] and T315 [compound 22 in ref. [51]], exhibited in vitro and/or in vivo antitumor efficacy in various types of cancer cells, in part, by targeting Akt activation. Here, AKT1 is linked to cancer.