SNAI1 and cancer: As ILK is known to promote the aggressive phenotype of cancer cells, in part, by facilitating epithelial-to-mesenchymal transition (EMT) through Snail upregulation [58], we examined the effect of ILK inhibition by genetic knockdown and T315 (2 μM) on the expression of Snail and the EMT markers E-cadherin and vimentin in PC-3 and MDA-MB-468 cells.