Dysregulated type 2 immunity in allergic asthma is characterized by an expansion of CD4+ Th2 cells and cytokines (IL-4, IL-5, IL-13), elevated total and allergen-specific IgE, eosinophilia, and airway inflammation and a counterbalance emergence of B1a cells with regulatory capacity [46]. This evidence concerns the gene IGHE and allergic asthma.