IGHE and airway hyperresponsiveness: Furthermore, removal of proteases from either A. fumigatus[13], American cockroach Per a 10 antigen [38], Epi p1 antigen from the fungus Epicoccum purpurascens[36] or Cur 11 antigen from the mold Curvularia Iunata[39] decreases their ability to promote IgE Abs secretion, airway inflammation and airway hyperresponsiveness in mouse models.