One notable feature of NRXN1 deletions, as for many rare pathogenic largely de novo CNVs [61]–[64], such as deletion of 15q13.3 [65]–[66], 16p11.2 [63], [67] and 1q21.1 [66], [68], is their association with a range of neurodevelopmental disorders including autism, schizophrenia, epilepsy and intellectual disability, i.e. they have pleiotropic effects [69]–[70]. This evidence concerns the gene NRXN1 and autism.