IGHE and helminthiasis: The reason for this discrepancy could not be addressed in this study but it might be due to the fact that helminth infection can potentially induce the production of false-positive serum IgE through cross-reactivity between helminth and aeroallergens as proposed earlier [21]: this is in line with the findings that sensitization to cockroach may not be driven by true cockroach exposure but by cross-reactive carbohydrate determinants (CCDs) as demonstrated in a study from Ghana (Akkerdaas J et al, manuscript in preparation).