Metabolic syndrome was associated with the presence of HALS (47.1% vs. 35.6%, OR = 1.61; 95%CI: 1.01.2.57, P = 0.0446) and with carriage of the HLA-B*40∶01 genotype (7.8% vs. 2.1%, OR = 4.04; 95%CI: 1.16–17.71, P = 0.0244). Here, HLA-B is linked to metabolic syndrome.