NKRF and acute respiratory distress syndrome: In this high mechanical stretch-induced ALI model in mice, we examined the relationships between high VT ventilation, iPSCs and iPSC-derived conditioned medium (iPSC-CM) production of MIP-2, intracellular oxidative stress, and activation of NF-κB and NKRF signaling using pharmacological inhibition with SN-50, a specific inhibitor for NF-κB and short interfering RNA (siRNA) targeted to NKRF.