Colony formation analysis showed that the depletion of MTA3 in H157 and A549 cells led to a significant reduction in the number and size of foci (A549 control vs MTA3si: 275±7 vs 81±10; H157 control vs MTA3si: 476±10 vs 276±32), suggesting that MTA3 modulates the proliferation of lung cancer cells (Figure 4). This evidence concerns the gene MTA3 and lung carcinoma.