TNF and Cirrhosis: The influence of the GG genotype at -238 position of TNF-α promoter gene was observed after a prolonged period: in fact, Kaplan Meier analysis demonstrated that curves of development of cirrhosis in function of the presence of genotypes GG or GA and AA at -238 position of TNF-α promoter gene begin to be clearly different after 20 years of evolution (Figure 2).