A possible explanation to the variable progression of liver fibrosis was provided by Wilson et al [20] with the demonstration that carriage of the -308 allele A, a much stronger transcriptional activator than -308 allele G in reporter gene assays, has direct effects on TNF-α gene regulation which may be responsible for the association with higher constitutive and inducible levels of TNF-α. This evidence concerns the gene TNF and Hepatic fibrosis.