APOE and hyperlipoproteinemia type 3: The APOE*3Leiden mouse was initially developed as an animal model for FD or type III hyperlipoproteinemia, which is characterized by elevated levels of cholesterol and an increased ratio of cholesterol to TG in the VLDL and intermediate density lipoprotein (IDL) fractions, resulting in the appearance of β-VLDL particles [31], [32].