APOE and hyperlipoproteinemia type 3: In this study, we aimed to address the discrepancy between the beneficial effects of niacin in initial clinical trials [3]–[6], [14] and the lack of effect of niacin on top of statin treatment on reduction of cardiovascular events in the AIM-HIGH [8] and HPS2-THRIVE [7] trials by investigating the effects of niacin without and with simvastatin on atherosclerosis development and determine the underlying mechanisms in APOE*3Leiden.CETP mice, a mouse model for familial dysbetalipoproteinemia (FD).