We genotyped six SNPs (TNF rs1799964T>C, LTA rs1800683G>A, IL–10 rs1800872T>G, LEP rs2167270G>A, LEPR rs1327118C>G, TNFAIP8 rs1045241C>T) and found that one SNP (rs1045241) in TNFAIP8 contributed to NHL susceptibility in a Chinese population. This evidence concerns the gene TNFAIP8 and non-Hodgkin lymphoma.