The decreased activity of NF-κB and increased activity of FOXO-3a led to decrease in the expression of anti-apoptotic proteins Bclxl and XIAP both in vitro and in vivo leading to induction of apoptosis as evidenced by flow cytometry in MDA-MB 231 and primary breast adenocarcinoma cells. Here, NFKB1 is linked to breast adenocarcinoma.