In the present study, we have examined the effects of 2-[piperidinoethoxyphenyl] -3- phenyl- 2H-benzo (b) pyran (CDRI-85/287) on EGFR -mediated signaling and cell survival/apoptosis in ER- negative human breast cancer cells and in xenograft mice model. Here, ESR1 is linked to breast carcinoma.