In addition to detecting a reduction in well described genes such as Vegfr-2 (Kdr; log2 fold change = −1.21, p = 0.008) and Dll4 (log2 fold change = −2.84, p = 0.03), a reduction in less well studied genes such as the Clec14a (log2 fold change = −1.77, p = 0.01), a tumour specific endothelial gene that regulates pro-angiogenic phenotypes [23], was also detected. This evidence concerns the gene DLL4 and neoplasm.