Further evidence suggesting a correlation between tau hyperphosphorylation and reduced methylation of PP2A arose from evidence suggesting high plasma homocysteine levels correlated with demethylated PP2A and Alzheimer's disease [74], and that downregulation of LCMT1 correlated with tau hyperphosphorylation [68]. The gene discussed is LCMT1; the disease is early-onset autosomal dominant Alzheimer disease.