For instance, EGCG from green tea is known to lower DNMT activity, leading to decreased DNA methylation of several known TS genes, such as p16INK4a, retinoic acid receptor β, and methylguanine methyltransferase, in human oesophageal, prostate, breast, and oral cancer cells lines [10], [12], [35]. The gene discussed is CDKN2A; the disease is lip and oral cavity carcinoma.