TGFB1 and Familial prostate cancer: Moreover, rs1982073 (T+29C) and rs1800469 (C-509T) have been linked with increased serum levels of TGFβ1 [26] and with the incidence of invasive breast cancer [27]; rs1800469 (C-509T) has also been linked with advanced-stage prostate cancer [26] and colon cancer [28].