Agliardi et al. [22] reported decreased MS risk for rs731236TT genotype in HLA-DRB1*15 positive individuals, and Cox et al. [19] reported a trend for increasing risk of MS in subjects who were homozygous for the HLADRB1*1501 (rs3135388) allele in association with rs2228570. This evidence concerns the gene HLA-DRB1 and myeloid sarcoma.