The CLL69C Ab resembles the BCR from a group of CLL cases (CLL22, CLL17, and CLL72) using the HCDR3 rearrangement (IGHV1-69/IGHD3-3/IGHJ6) and IGLV3-9-encoded light chain reported previously [40]. The gene discussed is BTK; the disease is B-cell chronic lymphocytic leukemia.