Although such accumulation of antibodies along the blood vessel is not very commonly noticed in the CNS autoimmune disease models, autoantibodies against a variety of CNS components including myelin basic protein, myelin-associated glycoprotein, neuronal cell-surface, -intracellular molecules, neuronal transmitter receptors, have been found to participate in demyelination and disease progression in the multiple sclerosis patients [44]–[47]. The gene discussed is MBP; the disease is autoimmune disease.