CYP3A4 and breast cancer: For instance, NR1I2 -25385C>T, -24113G>A, 7635A>G, or 8055C>T was reported to be associated with higher magnitude of induction of intestinal CYP3A by rifampin in vitro[18], but recently, the subjects with -25385C>T or TGT (-25385T+g.7635G+g.8055T) carriers were verified to have decreased CYP2B6 activity (AUC ratio) induced by rifampin in Korean, and NR1I2*1B (8055C>T+2654T>C) haplotype was strongly associated with its downstream target genes of MDR1 in Asian breast cancer patients [42].