Nevertheless, a hepatic protein has been identified, called fetuin-A (FetA), which is a major carrier of FFAs in the circulation [55], that acts as an endogenous ligand of TLR4, thus activating its signaling pathway, promoting insulin resistance, which was blocked in the absence of FetA, and attenuating insulin resistance induced by FFA [56]. Here, TLR4 is linked to Insulin resistance.