NLRP3 and metabolic dysfunction-associated steatohepatitis: The activation of DAMPs and PAMPs in the gut is necessary for the maintenance of barrier function, while nucleotide-binding oligomerization domain protein-like receptor 3 (NLRP3) and NLRP6-deficient mice show increased intestinal permeability and increased risk of colitis [28, 62], allowing the occurrence of dysbiosis and insulin resistance and a greater possibility of nonalcoholic steatohepatitis (NASH).