Proinflammatory cytokines, such as interleukin-1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), and interferon gamma (IFN-γ), secreted by activated lymphocytes and macrophages during insulitis, induce NFkB mediated iNOS expression which has a key role in β-cell apoptosis in the early T1DM stage [1]. This evidence concerns the gene NOS2 and type 1 diabetes mellitus.