Another 16-month trial [108] among Latin America countries also showed that the 7203 patients who received oral active vitamin D had significant reductions in overall, cardiovascular, infectious and neoplastic mortality compared to the 8801 patients that had not received vitamin D. Several trials using vitamin D analog paricalcitol in patients with CKD have noted significant reduction in albuminuria and the effects were independent of hemodynamics or parathyroid hormone suppression [111,112,113]. This evidence concerns the gene PTH and chronic kidney disease.