MMP9 and neoplasm: The role of platelets in tumor progression has been recently investigated, where it was found that platelet-derived microvesicles contribute to cancer progression in lung cancer cell lines by stimulating proliferation, cyclin D2 expression, adhesion to endothelial cells, invasion and angiogenesis through activation of mitogen-activated protein kinase (MAPK) p42/44, MT1-MMP, MMP-9, IL-8 and VEGF and other factors controlling these processes [80].