EPHB1 and autism: Other interesting differentially expressed genes included ephrin type-B receptor 1 (Ephb1), whose genetic deletion in mice causes neuronal loss in the substantia nigra and spontaneous locomotor hyperactivity,76 myeloid/lymphoid or mixed-lineage leukemia 2 (Mll2), whose activity is required for memory formation,77 and Churchill domain containing protein 1 (Churc1), a neuronal development gene implicated with the occurrence of autism.78