RAG1 and bipolar disorder: Synuclein-γ has been associated with Parkinson's disease67 and reported to be implicated in both cognitive and emotional functions.68 Von Willebrand factor has been shown to be significantly increased in schizophrenia,69, 70, 71 whereas changes in polycystic kidney disease 1 and tetratricopeptide repeat and ankyrin repeat containing 1) expression have been associated with bipolar disorders.72, 73, 74 S100a10, a recently suggested potential biomarker for suicide risk in mental disorders,75 was upregulated in RAG-1−/− and downregulated in RAG-1−/−/OT-II to WT level.