SLC9A1 and Ventricular hypertrophy: Several studies have demonstrated that sarcolemmal NHE1 dysfunction was closely related to cardiomyocyte death under pathophysiological conditions such as ischaemia-reperfusion injury, ventricular hypertrophy and myocardial infarction, underlying the pathophysiological importance of the fine-tuned NHE1 activity [3–6].