PGP and cancer: Upregulation of P-gp has previously been shown to increase cancer cells’ ability to efflux a wide variety of structurally unrelated chemotherapeutics such as Vinca alkaloids (Vincristine, Vinblastine), Anthracyclins (Doxorubicin [Dox], Daunorubicin), and Epipodophyllotoxins (Etoposide) [26-28].