TP53 and esophageal squamous cell carcinoma: Further supporting the notion that the inflammatory context caused by the consumption of beverages at high temperatures in the high-risk areas may account to the large proportion of transitions found at CpG sites of TP53, recently, a study performed in Golestan (Iran) observed that G to A transition, especially at CpG sites, occurs most frequently in ESCC from patients who drink tea at the highest temperatures [24].