In conclusion, the results of this study showed anti-asthmatic and anti-allergic ability of the S. striata extract through reducing the IL-4 and IL-5 cytokines production, total and specific-OVA IgE and also decreasing of eosinophils and total inflammatory cells in the BALF of OVA- sensitized /challenged mice asthma model. The gene discussed is IL4; the disease is asthma.