PRKCG and post-traumatic stress disorder: In the present study, visceral nociceptive responses to CRD following exposure to PTSD-like stress was blocked by GF109203X at the spinal level, suggesting that PKCγ inhibitors may be neuroprotective in disorders with dysregulated PKCγ signaling following PTSD-like stress, and thus, supporting that spinal PKCγ activation plays a functional role in the development of visceral hypersensitivity, and enhanced responsiveness after SPS exposure is dependent on PKCγ activation.