CASP3 and malignant colon neoplasm: Other studies identified that coumarin is able to induce cervical and colon cancer cell apoptosis by activating the mitochondrial pathway and the caspase-3-dependent apoptotic pathway, to downregulate the anti-apoptotic NF-κB, Bcl-2 and Bcl-xL, and upregulate caspase-3 to promote the release of cytochrome (cyt) c(9,10).