CASP3 and lung adenocarcinoma: In the present study, we used 7,8-dihydroxycoumarin to treat A549 lung adenocarcinoma cells and then performed qPCR and western blotting to detect the ability of 7,8-dihydroxycoumarin to change the levels of anti-apoptotic pAkt, pIκBα, pNF-κB p65 and Bcl-2, as well as pro-apoptotic caspase-3.