Routsias et al identified that the complementary peptide 289–308 amino acids of the SSB antigen share similar or identical amino acid sequences with Mycobacterium tuberculosis(23), Helicobacter pylori, Streptococcus, Escherichia coli and malaria parasites, suggesting that the anti-SSB antibody may simulate these biological agents and cause disease. This evidence concerns the gene SSB and malaria.