According to evidence-based data, CLP creates an inflammatory response after inducing sepsis, by increasing TNFα, IL-8 and ROS production, initiating apoptosis, decreasing mean arterial pressure and increasing lactate production (29–33)., However, limb IP appears to be a more feasible method for the treatment of the clinical conditions of patients with sepsis. This evidence concerns the gene CXCL8 and Sepsis.