ADIPOQ and obesity due to melanocortin 4 receptor deficiency: It has been reported from animal experiments, in which KKAy mice with high-fat diet-induced obesity were used, that AP reduces hyperglycemia and hyperinsulinemia by increasing adiponectin secretion and suppressing TNF-α secretion by white adipocytes, as well as by enhancing the expression of GLUT4 in skeletal muscle.