It has been reported from animal experiments, in which KKAy mice with high-fat diet-induced obesity were used, that AP reduces hyperglycemia and hyperinsulinemia by increasing adiponectin secretion and suppressing TNF-α secretion by white adipocytes, as well as by enhancing the expression of GLUT4 in skeletal muscle. The gene discussed is ADIPOQ; the disease is hyperinsulinism.