As a therapeutic target, CD83 has demonstrated utility in a variety of applications, from the use of soluble, recombinant CD83 in models of experimental autoimmune encephalomyelitis (EAE) and skin transplantation (18), to the use of depletion antibodies in the prevention of GVHD and giant-cell arteritis (GCA) in animal models. Here, CD83 is linked to experimental autoimmune encephalomyelitis.