LV-STI-1-shRNA injected 30 min post-cerebral ischemia in Prnp+/+ mice decreased STI-1 protein expression in a time-dependent manner (Fig 7B), and in line with the role of STI-1 in BMDC activity and stroke recovery, LV-STI-1-shRNA decreased BMDC recruitment (Fig 7C) and exacerbated cerebral infarction 3 day post-ischemia (Fig 7D) to the level seen in Prnp0/0 mice. This evidence concerns the gene PRNP and stroke disorder.