Moreover, based on the role of PrPC in stroke recovery (Weise et al, 2004; Weise et al, 2006) and the therapeutic efficacy of PrPC overexpression in experimental model of focal ischemia (Shyu et al, 2005; Weise et al, 2008), we further studied whether STI-1 may promote stroke recovery via activation of PrPC, and more importantly, whether this neuroprotection may come about in part through STI-1 mediated recruitment of BMDCs. The gene discussed is PRNP; the disease is stroke disorder.